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【结 构 式】 
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【分子编号】26015 【品名】2-[(E)-2-(3,5-dichlorophenyl)ethenyl]benzoic acid 【CA登记号】 |
【 分 子 式 】C15H10Cl2O2 【 分 子 量 】293.1486 【元素组成】C 61.46% H 3.44% Cl 24.19% O 10.92% |
合成路线1
该中间体在本合成路线中的序号：(IV)A process useful for the industrial preparation of eberconazole has been reported: The Wittig condensation of 2-(methoxycarbonyl)benzyl(triphenyl)phosphonium bromide (I) with 3,5-dichlorobenzaldehyde (II) by means of NaH in DMF gives 2-[2-(3,5-dichlorophenyl)vinyl]benzoic acid methyl ester (III), which is hydrolyzed with NaOH in methanol to the corresponding free acid (IV). The hydrogenation of (IV) with H2 over Pd/C in methanol affords 2-[2-(3,5-dichlorophenyl)ethyl]benzoic acid (V), which is cyclized to 2,4-dichloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one (VI) by means of polyphosphoric acid. The reduction of (VI) with NaBH4 yields the corresponding carbinol (VII), which is treated with SOCl2 affording the chloride (VIII). Finally, this compound is condensed with imidazole (IX) in refluxing DMF.
| 【1】 Farrerons Gallemi, C.; Monserrat Vidal, C.; Miquel Bono, I.J. (Laboratorios Salvat SA); Process for the preparation of eberconazol and intermediates thereof. WO 9921838 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 26013 | [2-(methoxycarbonyl)benzyl](triphenyl)phosphonium bromide | C27H24BrO2P | 详情 | 详情 | |
| (II) | 24169 | 3,5-dichlorobenzaldehyde | 10203-08-4 | C7H4Cl2O | 详情 | 详情 |
| (III) | 26014 | methyl 2-[(E)-2-(3,5-dichlorophenyl)ethenyl]benzoate | C16H12Cl2O2 | 详情 | 详情 | |
| (IV) | 26015 | 2-[(E)-2-(3,5-dichlorophenyl)ethenyl]benzoic acid | C15H10Cl2O2 | 详情 | 详情 | |
| (V) | 26016 | 2-(3,5-dichlorophenethyl)benzoic acid | C15H12Cl2O2 | 详情 | 详情 | |
| (VI) | 14362 | 2,4-dichloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one | C15H10Cl2O | 详情 | 详情 | |
| (VII) | 14363 | 2,4-dichloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol | C15H12Cl2O | 详情 | 详情 | |
| (VIII) | 14364 | 2,4,5-trichloro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene | C15H11Cl3 | 详情 | 详情 | |
| (IX) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |