(2R,3R,4R,5R)-4-(acetoxy)-2-[(acetoxy)methyl]-5-[2-chloro-6-(methoxyamino)-9H-purin-9-yl]tetrahydro-3-furanyl acetate -Drug Synthesis Database

【结构式】

【分子编号】25229

【品名】(2R,3R,4R,5R)-4-(acetoxy)-2-[(acetoxy)methyl]-5-[2-chloro-6-(methoxyamino)-9H-purin-9-yl]tetrahydro-3-furanyl acetate

【CA登记号】

【分子式】C₁₇H₂₀ClN₅O₈

【分子量】457.8274

【元素组成】C 44.6% H 4.4% Cl 7.74% N 15.3% O 27.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of 2,6-dichloro-9-(2',3',5'-tri-O-acetyl-beta-D-ribofuranosyl)-9H-purine (I) with O-methylhydroxylamine in hot dioxane gives 2',3',5'-tri-O-acetyl-2-chloro-N-methoxy-adenosine (II), which is then treated with sodium methoxide in methanol.

参考文献中间体

合成目标

【1】 Knutsen, L.; Olsen, U.B.; Roberts, S.M.; Varley, D.R.; Bowler, A.N. (Novo Nordisk A/S); Novel N-alkoxyadenine derivs. acting as cytokine inhibitors. WO 9801459 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	15455	(aminooxy)methane; O-methylhydroxylamine	67-62-9	CH₅NO	详情	详情
(I)	25228	(2R,3R,4R,5R)-4-(acetoxy)-2-[(acetoxy)methyl]-5-(2,6-dichloro-9H-purin-9-yl)tetrahydro-3-furanyl acetate		C₁₆H₁₆Cl₂N₄O₇	详情	详情
(II)	25229	(2R,3R,4R,5R)-4-(acetoxy)-2-[(acetoxy)methyl]-5-[2-chloro-6-(methoxyamino)-9H-purin-9-yl]tetrahydro-3-furanyl acetate		C₁₇H₂₀ClN₅O₈	详情	详情

Extended Information