4-chloro-2-methyl-N-[(E)-benzylidene]-2-butanamine -Drug Synthesis Database

【结构式】

【分子编号】24247

【品名】4-chloro-2-methyl-N-[(E)-benzylidene]-2-butanamine

【CA登记号】

【分子式】C₁₂H₁₆ClN

【分子量】209.71848

【元素组成】C 68.73% H 7.69% Cl 16.9% N 6.68%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of 1-(1-propen-2-yl)-2 benzimidazolinone (I) in hexamethylphosphorus triamide with sodium hydride and 3-benzalamino-3,3-dimethylpropyl chloride (II) and treating the reaction product with hydrochloric acid gives 1-(3 amino-3,3-dimethylpropyl)-2 benzimidazolone (III). The amine (III) is refluxed with 1-(1-naphthyloxy)propylene-(2,3)-oxide (IV) yielding the title compound.

参考文献中间体

合成目标

【1】 Hoefke, W.; et al. (Boehringer Ingelheim GmbH); 1-Aryloxy-2-hydroxy-3-[(benzimidazolin-one-substituted alkyl)-amino]-propanes and salts thereof. DE 2644833 .
【2】 Mentrup, A.; Palluk, R.; Gaida, W.; Hoefke, W.; Adimolol hydrochloride hydrate. Drugs Fut 1986, 11, 1, 9.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	24246	1-isopropenyl-1,3-dihydro-2H-benzimidazol-2-one	C₁₀H₁₀N₂O	详情	详情
(II)	24247	4-chloro-2-methyl-N-[(E)-benzylidene]-2-butanamine	C₁₂H₁₆ClN	详情	详情
(III)	24248	1-(3-amino-3-methylbutyl)-1,3-dihydro-2H-benzimidazol-2-one	C₁₂H₁₇N₃O	详情	详情
(IV)	22937	2-[(1-naphthyloxy)methyl]oxirane; 1-naphthyl 2-oxiranylmethyl ether	C₁₃H₁₂O₂	详情	详情

Extended Information