Phosphoric acid 2-aminoethyl hexadecyl diester inner salt -Drug Synthesis Database

【结构式】

【分子编号】23093

【品名】Phosphoric acid 2-aminoethyl hexadecyl diester inner salt

【CA登记号】

【分子式】C₁₉H₄₀O₄P

【分子量】363.497962

【元素组成】C 62.78% H 11.09% O 17.61% P 8.52%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

In scheme 14476001a hexadecanol is reacted with phosphoroxy chloride in the presence of triethylamine in tetrahydrofuran with subsequent condensation with ethanolamine in dioxane/triethylamine. Hydrolysis with aqueous hydrochloric acid and methylation with dimethyl sulfate in the presence of potassium carbonate yields hexadecyl phosphocholine.

参考文献中间体

合成目标

【1】 Schumacher, W.; Unger, C.; Berger, M.R.; Hilgard, P.; Eibl, H.J.; Schmahl, D.; Stekar, J.; Engel, J.; Nagel, G.; Hexadecylphocholine. Drugs Fut 1988, 13, 11, 948.
【2】 Kin, D.J.; Unger, C.; Berger, M.R.; Fleer, E.A.M.; Nagel, G.A.; Eibl, H.; Hexadecylphosphocholine, a new antineoplastic agent: cytotoxic properties in leukaemic cells. J Cancer Res Clin Oncol 1986, 111, 24.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	10259	Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol；2-Aminoethyl alcohol	141-43-5	C₂H₇NO	详情	详情
(I)	23090	1-hexadecanol	36653-82-4	C₁₆H₃₄O	详情	详情
(II)	23091	Dichlorophosphoric acid hexadecyl ester		C₁₆H₃₃Cl₂O₂P	详情	详情
(III)	23092	2-(hexadecyloxy)-1,3,2lambda(5)-oxazaphospholidin-2-one		C₁₈H₃₈NO₃P	详情	详情
(IV)	23093	Phosphoric acid 2-aminoethyl hexadecyl diester inner salt		C₁₉H₄₀O₄P	详情	详情

Extended Information