|
【结 构 式】 
|
【分子编号】23092 【品名】2-(hexadecyloxy)-1,3,2lambda(5)-oxazaphospholidin-2-one 【CA登记号】 |
【 分 子 式 】C18H38NO3P 【 分 子 量 】347.478422 【元素组成】C 62.22% H 11.02% N 4.03% O 13.81% P 8.91% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)In scheme 14476001a hexadecanol is reacted with phosphoroxy chloride in the presence of triethylamine in tetrahydrofuran with subsequent condensation with ethanolamine in dioxane/triethylamine. Hydrolysis with aqueous hydrochloric acid and methylation with dimethyl sulfate in the presence of potassium carbonate yields hexadecyl phosphocholine.
| 【1】 Schumacher, W.; Unger, C.; Berger, M.R.; Hilgard, P.; Eibl, H.J.; Schmahl, D.; Stekar, J.; Engel, J.; Nagel, G.; Hexadecylphocholine. Drugs Fut 1988, 13, 11, 948. |
| 【2】 Kin, D.J.; Unger, C.; Berger, M.R.; Fleer, E.A.M.; Nagel, G.A.; Eibl, H.; Hexadecylphosphocholine, a new antineoplastic agent: cytotoxic properties in leukaemic cells. J Cancer Res Clin Oncol 1986, 111, 24. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 10259 | Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol；2-Aminoethyl alcohol | 141-43-5 | C2H7NO | 详情 | 详情 | |
| (I) | 23090 | 1-hexadecanol | 36653-82-4 | C16H34O | 详情 | 详情 |
| (II) | 23091 | Dichlorophosphoric acid hexadecyl ester | C16H33Cl2O2P | 详情 | 详情 | |
| (III) | 23092 | 2-(hexadecyloxy)-1,3,2lambda(5)-oxazaphospholidin-2-one | C18H38NO3P | 详情 | 详情 | |
| (IV) | 23093 | Phosphoric acid 2-aminoethyl hexadecyl diester inner salt | C19H40O4P | 详情 | 详情 |
Extended Information