合成路线1

Pentafluoronitrobenzene (I) was reacted with NaNO2 in DMSO to give phenol (II), which was then protected as the allyl ether (IV) upon treatment with allyl bromide (III) and Na2CO3 in refluxing acetone. Further displacement of one fluorine atom of (III) with NaOH under phase transfer conditions afforded phenol (V). This was then attached to a solid phase carboxypolystyrene resin using diisopropyl carbodiimide (DIC) in the presence of pyridine and DMAP. Deprotection of the allyl ether from the resulting resin ester (VI) was accomplished with sodium p-toluenesulfinate and palladium catalyst to yield phenol (VII). The Mitsunobu etherification of phenol (VII) with farnesol (VIII) furnished farnesyl ether (IX). The final product was then cleaved from the resin by treatment with NaOMe in MeOH-THF.