6-methoxy-3,4-dihydro-1-naphthalenyl trifluoromethanesulfonate -Drug Synthesis Database

【结构式】

【分子编号】27726

【品名】6-methoxy-3,4-dihydro-1-naphthalenyl trifluoromethanesulfonate

【CA登记号】

【分子式】C₁₂H₁₁F₃O₄S

【分子量】308.2781496

【元素组成】C 46.75% H 3.6% F 18.49% O 20.76% S 10.4%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Condensation of of 2-iodoaniline (I) with vinyl triflate (II) in the presence of Pd(PPh3)4 and K2CO3 under atmosphere of CO produced the intermediate amide, which underwent an annellation reaction to the title benzoxazinone.

参考文献中间体

合成目标

【1】 Arcadi, A.; et al.; Synthesis and in vitro and in vivo evaluation of the 2-(6'methoxy-3',4'-dihydro-1'-naphtyl)-4H-3,1-benzoxazin-4-one as a new potent substrate inhibitor of human leukocyte elastase. Bioorg Med Chem Lett 1999, 9, 9, 1291.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	27725	2-iodoaniline	615-43-0	C₆H₆IN	详情	详情
(II)	27726	6-methoxy-3,4-dihydro-1-naphthalenyl trifluoromethanesulfonate		C₁₂H₁₁F₃O₄S	详情	详情
(III)	27727	N-(2-iodophenyl)-6-methoxy-3,4-dihydro-1-naphthalenecarboxamide		C₁₈H₁₆INO₂	详情	详情

Extended Information