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【结 构 式】 
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【分子编号】28740 【品名】rac-(N-ethyl-1-[3-(trifluoromethyl)phenyl]-2-propanamine) 【CA登记号】 |
【 分 子 式 】C12H16F3N 【 分 子 量 】231.2609896 【元素组成】C 62.32% H 6.97% F 24.65% N 6.06% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The (+) isomer of fenfluramine is obtained in the following way: The action of d-camphoric acid on (rac)-fenfluramine (I) forms the camphorate of (+)-fenfluramine (II). After purification of this salt by crystallization, sodium hydroxide in methylene chloride is added, forming (+)-fenfluramine (III) after removal of camphoric acid. Finally, the action of hydrogen chloride in methyl cyclohexane on (+)-fenfluramine produces the corresponding salt: (+)-fenfluramine hydrochloride.
| 【1】 Nathan, C.; Dexfenfluramine Hydrochloride. Drugs Fut 1987, 12, 9, 845. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 32569 | (1R,3S)-1,2,2-trimethyl-1,3-cyclopentanedicarboxylic acid; (+)-Camphoric acid | 124-83-4 | C10H16O4 | 详情 | 详情 |
| (I) | 28740 | rac-(N-ethyl-1-[3-(trifluoromethyl)phenyl]-2-propanamine) | C12H16F3N | 详情 | 详情 | |
| (II) | 65178 | C22H32F3NO4 | 详情 | 详情 | ||
| (III) | 28742 | (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]-2-propanamine | C12H16F3N | 详情 | 详情 |
Extended Information