phenyl 2-phenyl-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridin-8-yl sulfide; 2-phenyl-8-(phenylsulfanyl)-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridine -Drug Synthesis Database

【结构式】

【分子编号】23189

【品名】phenyl 2-phenyl-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridin-8-yl sulfide; 2-phenyl-8-(phenylsulfanyl)-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridine

【CA登记号】

【分子式】C₁₉H₂₀N₂S

【分子量】308.44728

【元素组成】C 73.99% H 6.54% N 9.08% S 10.4%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of 2-phenyl-2,3,5,6,7,8-hexahydro imidazo[1,2-a]pyridine (I) with diphenyl sulfide (II) by means of n-butyllithium in THF gives 2-phenyl-8-(phenylthio)-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridine (III), which is then oxidized with chloramine T in methanol and simultaneously ketalized.

参考文献中间体

合成目标

【1】 Murray, R.J.; Loch, J.T. III; Radov, L.A.; Davidson, T.A.; Kamp, D.; Trusso, L.A.; Gawlack, D.L.; Immunomodulatory pyrrolo[1,2-a]imidazoles and imidazol[1,2-a]pyridines. 192nd ACS Natl Meet (Sept 7-12, Anaheim) 1986, Abst MEDI-81.
【2】 Davidson, T.A.; Murray, R.J. (Pennwalt Corp.); Pyrrolo[1,2-a]imidazole and imidazo[1,2-a]pyridine. EP 0150255; US 4507481 .
【3】 Castaner, J.; Prous, J.; PR-879317A. Drugs Fut 1988, 13, 10, 934.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23187	2-phenyl-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridine		C₁₃H₁₆N₂	详情	详情
(II)	23188	1-(phenylsulfanyl)benzene; diphenyl sulfide	139-66-2	C₁₂H₁₀S	详情	详情
(III)	23189	phenyl 2-phenyl-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridin-8-yl sulfide; 2-phenyl-8-(phenylsulfanyl)-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridine		C₁₉H₂₀N₂S	详情	详情

Extended Information