|
【结 构 式】 
|
【分子编号】20525 【品名】2-([2-[(2-[[3-(acetamido)-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy]propanoyl)amino]propanoyl]amino)-N(5)-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-2-oxoethyl]pentanediamide 【CA登记号】 |
【 分 子 式 】C26H40N6O14 【 分 子 量 】660.63564 【元素组成】C 47.27% H 6.1% N 12.72% O 33.91% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)1) The esterification of N-acetylmuramyl-L-alanyl-D-glutaminyl-L-alanine (I) with N-hydroxysuccinimide (II) by means of dicyclohexylcarbodiimide in dimethylacetamide gives the corresponding N-hydroxysuccinimide ester (III), which is then to condensed with O-(1,2-dipalmitoyl-sn-glycero-3-phosphoryl)ethanolamine (IV) by means of triethylamine in the same solvent.
| 【1】 Baschang, G.; Carcsay, L.; Hartmann, A.; Stanek, J. (Novartis AG); Phosphorylmuramyl peptides, process for their preparation and use. EP 0027258 . |
| 【2】 Slusarchyk, W.A.; Dejneka, T.; Kostes, W.H. (Bristol-Myers Squibb Co.); Preparation of 4,4-dialkyl-2-azetidinones. AU 8652460; BE 090411; DE 3602347; ES 8706112; ES 8800897; FR 2576596; GB 2170201; US 4638061 . |
| 【3】 Prous, J.; Castaner, J.; ENV 2-3/MTP-PE. Drugs Fut 1989, 14, 3, 220. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 20523 | N-[4-([2-[(2-[[3-(acetamido)-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy]propanoyl)amino]propanoyl]amino)-5-amino-5-oxopentanoyl]alanine | C22H37N5O12 | 详情 | 详情 | |
| (II) | 10264 | 1-Hydroxydihydro-1H-pyrrole-2,5-dione; N-Hydroxysuccinimide; 1-Hydroxy-2,5-pyrrolidinedione | 6066-82-6 | C4H5NO3 | 详情 | 详情 |
| (III) | 20525 | 2-([2-[(2-[[3-(acetamido)-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy]propanoyl)amino]propanoyl]amino)-N(5)-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-2-oxoethyl]pentanediamide | C26H40N6O14 | 详情 | 详情 | |
| (IV) | 20526 | 2-[[(2-aminoethoxy)(hydroxy)phosphoryl]oxy]-1-[(palmitoyloxy)methyl]ethyl palmitate | 923-61-5 | C37H74NO8P | 详情 | 详情 |
Extended Information