|
【结 构 式】 
|
【分子编号】19570 【品名】4-bromo-1-(chloromethyl)-2-fluorobenzene 【CA登记号】 |
【 分 子 式 】C7H5BrClF 【 分 子 量 】223.4718032 【元素组成】C 37.62% H 2.26% Br 35.76% Cl 15.86% F 8.5% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)3) The alkylation of 2-amino-4-chlorobenzamide (X) with ethyl bromoacetate (VI) by means of K2CO3 in hot DMF gives ethyl 2-(2-carbamoyl-4-chlorophenylamino)acetate (XI), which is cyclized with CDI at 150 C yielding ethyl 7-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-1-acetate (XII). Finally, this compound is alkylated with 4-bromo-2-fluorobenzyl chloride (XIII) by means of NaH in DMF to afford quinazoline (VII) already obtained.
| 【1】 Hashimoto, M.; Oku, T.; Ito, Y.; Namiki, T.; Sawada, K.; Kasahara, C.; Baba, Y. (Fujisawa Pharmaceutical Co., Ltd.); New quinazoline derivs., process for their production and pharmaceutical compsns. comprising them. EP 0218999; JP 1987096476; JP 1989125322; JP 1989131164; US 4734419; US 4883800 . |
| 【2】 Prous, J.; Castaner, J.; FR-74366. Drugs Fut 1989, 14, 1, 26. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 16640 | Ethyl 2-bromoacetate; Ethyl bromoacetate | 105-36-2 | C4H7BrO2 | 详情 | 详情 |
| (VII) | 19564 | ethyl 2-[3-(4-bromo-2-fluorobenzyl)-7-chloro-2,4-dioxo-3,4-dihydro-1(2H)-quinazolinyl]acetate | C19H15BrClFN2O4 | 详情 | 详情 | |
| (X) | 19567 | 2-amino-4-chlorobenzamide | C7H7ClN2O | 详情 | 详情 | |
| (XI) | 19568 | ethyl 2-[2-(aminocarbonyl)-5-chloroanilino]acetate | C11H13ClN2O3 | 详情 | 详情 | |
| (XII) | 19569 | ethyl 2-[7-chloro-2,4-dioxo-3,4-dihydro-1(2H)-quinazolinyl]acetate | C12H11ClN2O4 | 详情 | 详情 | |
| (XIII) | 19570 | 4-bromo-1-(chloromethyl)-2-fluorobenzene | C7H5BrClF | 详情 | 详情 |
Extended Information