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【结 构 式】 
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【分子编号】13419 【品名】N-[3-(8-Allyl-8-propyl-2-azaspiro[4.5]dec-2-yl)propyl]-N,N-dimethylamine; 3-(8-Allyl-8-propyl-2-azaspiro[4.5]dec-2-yl)-N,N-dimethyl-1-propanamine 【CA登记号】 |
【 分 子 式 】C20H38N2 【 分 子 量 】306.5352 【元素组成】C 78.37% H 12.5% N 9.14% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The synthesis of two different forms of tritiated SK&F-105685 has been described: 1) The reaction of SK&F-105685 (I) with mercuric acetate and perchloric acid gives the corresponding iminium perchlorate (II), which is then reduced with NaBT4 in ethanol yielding the tritium derivative at C-1. 2) The reductive tritiation of the 8-allyl-2-[3-(dimethylamino)propyl]-8-propyl-2-azaspiro[4.5]decane (III) with tritium gas over Pd/C in ethanol gives the ditritiated compound at the propyl.
| 【1】 Landvatter, S.W.; Heys, J.R.; Senderoff, S.G.; Synthesis of the tritium labelled azaspirane: SK&F 105685. J Label Compd Radiopharm 1993, 33, 12, 1113. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13416 | N-[3-(8,8-Dipropyl-2-azaspiro[4.5]dec-2-yl)propyl]-N,N-dimethylamine; 3-(8,8-Dipropyl-2-azaspiro[4.5]dec-2-yl)-N,N-dimethyl-1-propanamine | C20H40N2 | 详情 | 详情 | |
| (II) | 13417 | 2-[3-(Dimethylamino)propyl]-8,8-dipropyl-2-azoniaspiro[4.5]dec-1-ene | C20H39N2 | 详情 | 详情 | |
| (III) | 13419 | N-[3-(8-Allyl-8-propyl-2-azaspiro[4.5]dec-2-yl)propyl]-N,N-dimethylamine; 3-(8-Allyl-8-propyl-2-azaspiro[4.5]dec-2-yl)-N,N-dimethyl-1-propanamine | C20H38N2 | 详情 | 详情 |
Extended Information