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【结 构 式】 
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【分子编号】12946 【品名】ethyl (2R)-2-[(2-[[(1R)-2-ethoxy-2-oxo-1-(sulfanylmethyl)ethyl]amino]ethyl)amino]-3-sulfanylpropanoate 【CA登记号】 |
【 分 子 式 】C12H24N2O4S2 【 分 子 量 】324.46564 【元素组成】C 44.42% H 7.46% N 8.63% O 19.72% S 19.77% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The reductive dimerization of thiazolidine-4(R)-carboxylic acid sodium salt (I) with Na in liquid ammonia gives N,N-ethylene-1,2-diylbis(cysteine) (II), which is esterified with ethanol and dry HCl to the corresponding diethyl ester (III). Finally, this compound is treated with sodium pertechnetate and a reducing agent such as stannous salts, NaBH4 or Na2S2O4.
| 【1】 Castaner, J.; Robinson, C.; Technetium (Tc99m) Bicisate. Drugs Fut 1995, 20, 3, 251. |
| 【2】 Bergstein, P.L.; Cheesman, E.H.; Watson, A.D. (DuPont Pharmaceuticals Co.); Ester-substd. diaminedithiols and radiolabeled complexes thereof. AU 8811748; EP 0279417; JP 1988285549 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12944 | sodium (4R)-1,3-thiazolidine-4-carboxylate | C4H6NNaO2S | 详情 | 详情 | |
| (II) | 12945 | (2R)-2-[(2-[[(1R)-1-Carboxy-2-sulfanylethyl]amino]ethyl)amino]-3-sulfanylpropionic acid | C8H16N2O4S2 | 详情 | 详情 | |
| (III) | 12946 | ethyl (2R)-2-[(2-[[(1R)-2-ethoxy-2-oxo-1-(sulfanylmethyl)ethyl]amino]ethyl)amino]-3-sulfanylpropanoate | C12H24N2O4S2 | 详情 | 详情 |
Extended Information