(1R,5S)-1-Amino-9-methyl-9azabicyclo[3.3.1]nonane; (1R,5S)-9-Methyl-9-azabicyclo[3.3.1]non-3-ylamine; (1R,5S)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine; 1-Amino-9-methyl-9-azabicyclo[3.3.1]nonane -Drug Synthesis Database

【结构式】

【分子编号】11887

【品名】(1R,5S)-1-Amino-9-methyl-9azabicyclo[3.3.1]nonane; (1R,5S)-9-Methyl-9-azabicyclo[3.3.1]non-3-ylamine; (1R,5S)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine; 1-Amino-9-methyl-9-azabicyclo[3.3.1]nonane

【CA登记号】76272-56-5

【分子式】C₉H₁₈N₂

【分子量】154.2554

【元素组成】C 70.08% H 11.76% N 18.16%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The synthesis of granisetron has been reported: The reaction of 1-methylindazole-3-carboxylic acid (I) with oxalyl chloride and DMF in dichloromethane gives 1-methylindazole-3-carbonyl chloride (II), which is then condensed with endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine (III) by means of triethylamine in dichloromethane.

参考文献中间体

合成目标

【1】 GB 2125398 .
【2】 King, F.D. (SmithKline Beecham plc); Indazolyl carboxylic acid amides useful for treating migraine clusters headache, trigeminal neuralgia or emesis. AU 8656579; EP 0200444; EP 0223385; EP 0498466; ES 8707948; JP 1986275276; JP 1993194508; US 4886808; US 5034398 .
【3】 King, F.D.; Sanger, G.J.; 5-HT3 RECEPTOR ANTAGONISTS. Drugs Fut 1989, 14, 9, 875.
【4】 W.D.; Sanger, G.J.; 5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives. J Med Chem 1990, 33, 7, 1924-9.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11885	1-Methyl-1H-indazole-3-carboxylic acid	50890-83-0	C₉H₈N₂O₂	详情	详情
(II)	11886	1-Methyl-1H-indazole-3-carbonyl chloride	106649-02-9	C₉H₇ClN₂O	详情	详情
(III)	11887	(1R,5S)-1-Amino-9-methyl-9azabicyclo[3.3.1]nonane; (1R,5S)-9-Methyl-9-azabicyclo[3.3.1]non-3-ylamine; (1R,5S)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine; 1-Amino-9-methyl-9-azabicyclo[3.3.1]nonane	76272-56-5	C₉H₁₈N₂	详情	详情

Extended Information