2-Selanyl-N-phenylbenzenecarboximidic acid dilithium salt -Drug Synthesis Database

【结构式】

【分子编号】10250

【品名】2-Selanyl-N-phenylbenzenecarboximidic acid dilithium salt

【CA登记号】

【分子式】C₁₃H₉Li₂NOSe

【分子量】288.0626

【元素组成】C 54.2% H 3.15% Li 4.82% N 4.86% O 5.55% Se 27.41%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

A new synthesis of ebselen has been reported: The reaction of benzanilide (I) first with lithium diisopropylamide and then with butyllithium in THF gives the dianion (II), which is treated with freshly sublimed selenium to afford the insertion dianion (III). Finally, this compound is cyclized with CuBr2 in the same solvent. This reaction has also been carried out with 77Se in order to obtain labeled ebselen.

参考文献中间体

合成目标

【1】 Oppenheimer, J.; Silks, L.A.; Synthesis of 2-phenyl-1,2-benziso[Se-77]selenazol-3(2H)-one: 'Ebselen'. J Label Compd Radiopharm 1996, 38, 3, 281.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10248	N-Phenylbenzamide; Benzanilide	93-98-1	C₁₃H₁₁NO	详情	详情
(II)	10249	2-Lithio-N-phenylbenzenecarboximidic acid lithium salt		C₁₃H₉Li₂NO	详情	详情
(III)	10250	2-Selanyl-N-phenylbenzenecarboximidic acid dilithium salt		C₁₃H₉Li₂NOSe	详情	详情

Extended Information