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【结 构 式】 
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【分子编号】10249 【品名】2-Lithio-N-phenylbenzenecarboximidic acid lithium salt 【CA登记号】 |
【 分 子 式 】C13H9Li2NO 【 分 子 量 】209.1026 【元素组成】C 74.67% H 4.34% Li 6.64% N 6.7% O 7.65% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)A new synthesis of ebselen has been reported: The reaction of benzanilide (I) first with lithium diisopropylamide and then with butyllithium in THF gives the dianion (II), which is treated with freshly sublimed selenium to afford the insertion dianion (III). Finally, this compound is cyclized with CuBr2 in the same solvent. This reaction has also been carried out with 77Se in order to obtain labeled ebselen.
| 【1】 Oppenheimer, J.; Silks, L.A.; Synthesis of 2-phenyl-1,2-benziso[Se-77]selenazol-3(2H)-one: 'Ebselen'. J Label Compd Radiopharm 1996, 38, 3, 281. |
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