|
【结 构 式】 
|
【药物名称】 【化学名称】5-(2-Aminoethylamino)-1-phenylpentan-2-one 【CA登记号】 【 分 子 式 】C13H20N2O 【 分 子 量 】220.31715 |
【开发单位】Elpen (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Peripheral Vascular Disease, Treatment of, Free Radical Scavengers, Non-Steroidal Antiinflammatory Drugs |
合成路线1
Addition of benzylmagnesium bromide to 4-chlorobutyronitrile (II) gives rise to the chloro ketone adduct (III). Subsequent chloride displacement with ethylenediamine (IV) furnishes the target diamino ketone.
| 【1】 Andreadou, I.; Rekka, E.A.; Demopoulos, V.J.; Bijloo, G.J.; Kourounakis, P.N.; Synthesis, antioxidant and anti-inflammatory activity of novel substituted ethylenediamines and ethanolamines. A preliminary quantitative structure-activity relationship study. Arzneim-Forsch Drug Res 1997, 47, 5, 643. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28308 | benzyl(bromo)magnesium; benzylmagnesium bromide | 1589-82-8 | C7H7BrMg | 详情 | 详情 |
| (II) | 11179 | 4-Chlorobutanenitrile; 4-Chlorobutyronitrile | 628-20-6 | C4H6ClN | 详情 | 详情 |
| (III) | 64973 | 5-chloro-1-phenyl-2-pentanone | C11H13ClO | 详情 | 详情 | |
| (IV) | 14754 | ethylenediamine;1,2-Diaminoethane;ethane-1,2-diamine；1,2-Ethanediamine | 107-15-3 | C2H8N2 | 详情 | 详情 |
Extended Information