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【结 构 式】 
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【药物名称】 【化学名称】N-[3-(Benzyloxy)phenyl]-N'-hydroxyoctanediamide 【CA登记号】 【 分 子 式 】C21H26N2O4 【 分 子 量 】370.45237 |
【开发单位】Aton Pharma (Originator) 【药理作用】ONCOLYTIC DRUGS, Histone Deacetylase (HDAC) Inhibitors |
合成路线1
3-(Benzyloxy)aniline (I) is acylated by suberic acid mono-methyl ester (II) either employing EDC as the coupling reagent or via activation with oxalyl chloride to produce the suberoyl anilide (III). Further displacement of the methyl ester group of (III) with hydroxylamine in the presence of NaOMe leads to the target hydroxamic acid
| 【1】 Belvedere, S.; Zhou, W.; Witter, D.; Yan, J.; Chen, W.; Secrist, J.P.; Richon, V.; Miller, T.; SAHA derived inhibitors of histone deacetylase (HDAC). 225th ACS Natl Meet (March 23 2003, New Orleans) 2003, Abst MEDI 102. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 63471 | 3-[(phenylmethyl)oxy]aniline; 3-[(phenylmethyl)oxy]phenylamine | C13H13NO | 详情 | 详情 | |
| (II) | 56374 | Methyl hydrogen octane-1,8-dioate; Monomethyl suberate; Octanedioic acid monomethyl ester; Suberic acid monomethyl ester | 3946-32-5 | C9H16O4 | 详情 | 详情 |
| (III) | 63472 | methyl 8-oxo-8-({3-[(phenylmethyl)oxy]phenyl}amino)octanoate | C22H27NO4 | 详情 | 详情 |
Extended Information