-Drug Synthesis Database

【结构式】

【药物名称】

【化学名称】4-[1-(4-Fluorophenyl)-2-methyl-5-phenyl-1H-pyrrol-3-ylmethyl]thiomorpholine

【CA登记号】

【分子式】C₂₂H₂₃FN₂S

【分子量】366.50441

【开发单位】Università degli Studi "La Sapienza" (Originator), Università degli Studi di Cagliari (Originator), Università degli Studi di Siena (Originator)

【药理作用】ANTIINFECTIVE THERAPY, Antimycobacterial Agents

合成路线1

Condensation between 1-phenyl-1,4-pentanedione (I) and 4-fluoroaniline (II) under Paal-Knorr reaction conditions provides the pyrrole derivative (III). This is then subjected to Mannich reaction with thiomorpholine (IV) and formaldehyde to furnish the target thiomorpholimomethyl pyrrole.

参考文献中间体

【1】 Biava, M.; Porretta, G.C.; Deidda, D.; Pompei, R.; Tafi, A.; Manetti, F.; Importance of the thiomorpholine introduction in new pyrrole derivatives as antimycobacterial agents analogues of BM 212. Bioorg Med Chem 2003, 11, 4, 515.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	64413	1-phenyl-1,4-pentanedione		C₁₁H₁₂O₂	详情	详情
(II)	37690	4-fluorophenylamine; 4-fluoroaniline	371-40-4	C₆H₆FN	详情	详情
(III)	64414	1-(4-fluorophenyl)-2-methyl-5-phenyl-1H-pyrrole		C₁₇H₁₄FN	详情	详情
(IV)	36317	thiomorpholine	123-90-0	C₄H₉NS	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)