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【结 构 式】 
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【药物名称】 【化学名称】N,N'-(Octane-1,8-diyl)bis[6-[N-ethyl-N-(2-methoxybenzyl)amino]-N-methylhexanamide] dioxalate 【CA登记号】 【 分 子 式 】C46H74N4O12 【 分 子 量 】875.12228 |
【开发单位】Università degli Studi di Bologna (Originator), Università degli Studi di Camerino (Originator) 【药理作用】Alzheimer's Dementia, Treatment of , Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, Acetylcholinesterase Inhibitors, Muscarinic M2 Antagonists |
合成路线1
Condensation of diamine (I) with 2-methoxybenzaldehyde (II), followed by NaBH4 reduction of the intermediate bis-imine (III) gives rise to the benzylic amine (IV). This is then alkylated with diethyl sulfate, and the resultant N-ethyl amine is finally isolated as the corresponding dioxalate salt.
| 【1】 Tumiatti, V.; Rosini, M.; Bartolini, M.; Cavalli, A.; Marucci, G.; Andrisano, V.; Angeli, P.; Banzi, R.; Minarini, A.; Recanatini, M.; Melchiorre, C.; Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine. J Med Chem 2003, 46, 6, 954. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25375 | 6-amino-N-[8-[(6-aminohexanoyl)(methyl)amino]octyl]-N-methylhexanamide | C22H46N4O2 | 详情 | 详情 | |
| (II) | 12568 | 2-Methoxybenzaldehyde; o-Methoxybenzaldehyde | 135-02-4 | C8H8O2 | 详情 | 详情 |
| (III) | 64038 | N-methyl-N-(8-{methyl[6-({[2-(methyloxy)phenyl]methylidene}amino)hexanoyl]amino}octyl)-6-({[2-(methyloxy)phenyl]methylidene}amino)hexanamide | C38H58N4O4 | 详情 | 详情 | |
| (IV) | 25376 | 6-[(2-methoxybenzyl)amino]-N-[8-[[6-[(2-methoxybenzyl)amino]hexanoyl](methyl)amino]octyl]-N-methylhexanamide | C38H62N4O4 | 详情 | 详情 |
Extended Information