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【结 构 式】 
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【药物名称】PH-027 【化学名称】3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5(R)-(1H-1,2,3-triazol-1-ylmethyl)oxazolidin-2-one 【CA登记号】 【 分 子 式 】C16H18FN5O3 【 分 子 量 】347.35196 |
【开发单位】Kuwait University (Originator) 【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY, Oxazolidinones |
合成路线1
The known oxazolidine methansulfonate (I) is reacted with NaN3 in hot DMF to produce azide (II). Then, condensation of azide (II) with acetylene (III) at 90 C in a pressure vessel gives rise to the target triazole derivative.
| 【1】 Phillips, O.A.; Udo, E.E.; Ali, A.A.M.; Al-Hassawi, N.; Synthesis and antibacterial activity of 5-substituted oxazolidinones. Bioorg Med Chem 2003, 11, 1, 35. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17019 | [(5R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-1,3-oxazolan-5-yl]methyl methanesulfonate | 174649-09-3 | C15H19FN2O6S | 详情 | 详情 |
| (II) | 17020 | (5R)-5-(azidomethyl)-3-(3-fluoro-4-morpholinophenyl)-1,3-oxazolan-2-one | C14H16FN5O3 | 详情 | 详情 | |
| (III) | 23634 | acetylene | 74-86-2 | C2H2 | 详情 | 详情 |
Extended Information