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【结 构 式】 
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【药物名称】 【化学名称】N-Butyl-2-(4-fluorophenyl)acetamide 【CA登记号】 【 分 子 式 】C12H16FNO 【 分 子 量 】209.26582 |
【开发单位】China Medical College (Originator), Chung Shan Medical University (Originator), Taichung Veterans General Hospital (Originator) 【药理作用】ONCOLYTIC DRUGS, Apoptosis Inducers |
合成路线1
4-Fluorophenylacetic acid (I) is chlorinated by means of SOCl2 in refluxing benzene. The resultant acid chloride (II) is then reacted with butylamine (III) to produce the target amide
| 【1】 Chan, H.C.; et al.; 4-Fluoro-N-butylphenylacetamide: A synthetic phenylacetate derivative that upregulates Bcl-X-S, activates caspase cascade and induces apoptosis in human squamous lung cancer CH27 cells. Cancer Lett 2002, 186, 2, 211. |
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