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【结 构 式】 
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【药物名称】DL-262 【化学名称】3-(1,2-Diphenylethyl)-1,4,5,6-tetrahydro-1,2,4-triazine hydrochloride 【CA登记号】24638-35-5, 21038-20-0 (free base) 【 分 子 式 】C17H20ClN3 【 分 子 量 】301.82205 |
【开发单位】 【药理作用】 |
合成路线1
The reaction of aziridine (I) with hydrazine gives aminoethylhydrazine (II) (1), which is then cyclized with ethyl 2,3-diphenylpropionimidate hydrochloride (III) in ethanol. (1,2)
| 【1】 Trepanier, D.L. (Dow Chem. Co.); US 3471486 . |
| 【2】 Trepanier, D.L.; et al.; Vitrase approved by FDA as spreading agent; phase III results in vitreous hemorrhage also presented. J Med Chem 1969, 12, 2, 257. |
| 【3】 Castaner, J.; Hillier, K.; DL - 262. Drugs Fut 1979, 4, 3, 196. |
Extended Information