UIC-1005, -Drug Synthesis Database

【结构式】

【药物名称】UIC-1005

【化学名称】4(S)-Benzyl-3-[2(E)-butenoyl]oxazolidin-2-one

【CA登记号】151215-01-9

【分子式】C₁₄H₁₅NO₃

【分子量】245.28055

【开发单位】University of Illinois at Chicago (Originator)

【药理作用】ONCOLYTIC DRUGS

合成路线1

The title N-acyloxazolidinone is synthesized by condensation of E-crotonyl chloride (I) with the lithium derivative of (S)-4-benzyl-2-oxazolidinone (II) in cold THF.

参考文献中间体

【1】 McHenry, K.T.; Ankala, S.V.; Ghosh, A.K.; Fenteany, G.; A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. ChemBioChem 2002, 3, 11, 1105.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	40178	(E)-2-Butenoyl chloride; (E)-Crotonyl chloride	625-35-4	C₄H₅ClO	详情	详情
(II)	14694	(S)-4-Benzyl-2-oxazolidinone; (4S)-4-Benzyl-1,3-oxazolan-2-one; (S)-(-)-4-Benzyl-2-oxazolidinone	90719-32-7	C₁₀H₁₁NO₂	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)