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【结 构 式】 
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【药物名称】MJ 10459-2 【化学名称】5-(3,4-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrobromide 【CA登记号】40659-00-5(free base) 【 分 子 式 】C9H10BrCl2N3 【 分 子 量 】311.01015 |
【开发单位】 【药理作用】 |
合成路线1
It is prepared through the following sequence: The Strecker reaction of 3,4-dichlorobenzaldehyde (I) with sodium cyanide and NH4Cl affords alpha-amino-3,4-dichlorophenylacetonitrile (II) (HCl salt, m.p. 184-5 C), which is reduced with LiAlH4 to 2-amino-1-(3',4'-dichlorophenyl)ethylamine (III) (di HCl salt, m.p. 283-5 C). Finally compound (III) is cyclized with BrCN in benzene.
| 【1】 Castaner, J.; Blancafort, P.; M J 10459 - 2. Drugs Fut 1976, 1, 5, 250. |
| 【2】 Mathier, W.L.; et al.; 9-Cis retinoic acid enhances the effectiveness of PPARgamma-specific agonists in non-small cell lung cancer (NSCLC) cell lines. J Med Chem 1973, 16, 901. |
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