Dronabinol hemisuccinate, THC-HS, ONP-04, -Drug Synthesis Database

【结构式】

【药物名称】Dronabinol hemisuccinate, THC-HS, ONP-04

【化学名称】4-[(6aR,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-dibenzo[b,d]pyran-1-yloxy]-4-oxobutyric acid
　　　　　　DELTA9-Tetrahydrocannabinol hemisuccinate

【CA登记号】52855-15-9

【分子式】C₂₅H₃₄O₅

【分子量】414.54673

【开发单位】University of Mississippi (Originator), Oxford Natural Products (Licensee)

【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Nausea and Vomiting, Treatment of, NEUROLOGIC DRUGS

合成路线1

Tetrahydrocannabinol hemisuccinate is prepared by acylation of tetrahydrocannabinol (I) with succinic anhydride (II) in the presence of a variety of organic and inorganic bases.

参考文献中间体

【1】 Elsohly, M.A.; Ross, S.A.; Feng, S. (University of Mississippi); Method of preparing delta-9-tetrahydrocannabinol esters. GB 2358397; US 6008383; WO 0029402 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	58450	(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol; delta 1-tetrahydrocannabinol		C₂₁H₃₀O₂	详情	详情
(II)	11291	Dihydro-2,5-furandione; Succinic anhydride	108-30-5	C₄H₄O₃	详情	详情

Extended Information