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【结 构 式】 
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【药物名称】 【化学名称】2-[2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)quinolin-4-ylamino]ethanol 【CA登记号】332181-97-2, 332180-41-3 (hydrochloride) 【 分 子 式 】C20H21N3O 【 分 子 量 】319.40987 |
【开发单位】Roche (Originator) 【药理作用】Cerebrovascular Diseases, Treatment of, Ischemic Stroke, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, NR1/2B Antagonists |
合成路线1
Regioselective substitution of the 2-chloro group of 2,4-dichloroquinoline (I) with 1,2,3,4-tetrahydroisoquinoline (II) in refluxing toluene provides the 2-(tetrahydroisoquinolinyl)quinoline (III). Then, displacement of the remaining 4-chloro group by heating with ethanolamine (IV) furnishes the title compound
| 【1】 Pinard, E.; Alanine, A.; Bourson, A.; Buttelman, B.; Heitz, M.-P.; Mutel, V.; Gill, R.; Trube, G.; Wyler, R.; 4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists. Bioorg Med. Chem. Lett 2002, 12, 18, 2615. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 61332 | 2,4-Dichloroquinoline | C9H5Cl2N | 详情 | 详情 | |
| (II) | 14124 | 1,2,3,4-Tetrahydroisoquinoline | 91-21-4 | C9H11N | 详情 | 详情 |
| (III) | 61333 | 4-chloro-2-[3,4-dihydro-2(1H)-isoquinolinyl]quinoline | C18H15ClN2 | 详情 | 详情 | |
| (IV) | 10259 | Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol；2-Aminoethyl alcohol | 141-43-5 | C2H7NO | 详情 | 详情 |
Extended Information