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【结 构 式】 
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【药物名称】EP-1112 【化学名称】Acetic acid (4R,5S,6S,7R,9R,10R,14R)-6-[3,6-dideoxy-4-O-[2,6-dideoxy-3-C-methyl-4-O-(3-methylbutyryl)-alpha-L-ribo-hexopyranosyl]-3-(dimethylamino)-beta-D-glucopyranosyl]-10-(dimethylamino)-5-methoxy-9,14-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclotetradec-11-en-4-yl ester 【CA登记号】446024-54-0 【 分 子 式 】C42H72N2O14 【 分 子 量 】829.04714 |
【开发单位】Enanta Pharmaceuticals (Originator) 【药理作用】Antibiotics, ANTIINFECTIVE THERAPY, Macrolides |
合成路线1
The oxidation of Josamycin (I) with CrO3 and pyridine, followed by reaction with Ac2O, AcCl and methanol gives the macrocyclic dimethyl acetal (II), which is treated with NaBH4 and a Ru catalyst to promote a ring contraction yielding the 14-member macrocycle (III). The reaction of (III), first with MsCl and TEA, and then with NaN3 affords the azido macrocycle (IV), which is reduced with PPh3 in THF/water to provide the amino compound (V). The reductive methylation of (V) with CH2O and NaBH3CN gives the dimethylamino compound (VI). Finally, compound (VI) is treated with TFA in acetonitrile to furnish the target 14-member macrocyclic lactone.
| 【1】 Vo, N.H.; Wang, J.; Haley, T.; Napper, A.; Phan, L.T.; Or, Y.; 9-Amino derivatives of novel 14-membered ring macrolide antibiotics derived from leucomycins: Chemistry and in vitro biological activities. 42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002, Abst F-1664. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 62001 | (2S,3S,4R,6R)-6-{[(2R,3S,4R,5R,6R)-6-{[(4R,5R,6S,8R,9R,10R,16R)-4-(acetyloxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-8-(2-oxoethyl)oxa-11,13-cyclohexadecadien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate | C42H69NO15 | 详情 | 详情 | |
| (II) | 62002 | (2S,3S,4R,6R)-6-{[(2R,3S,4S,5R,6R)-5-(acetyloxy)-6-{[(4R,5R,6S,8R,9R,16R)-4-(acetyloxy)-8-(2,2-dimethoxyethyl)-5-methoxy-9,16-dimethyl-2,10-dioxooxa-11,13-cyclohexadecadien-6-yl]oxy}-4-(dimethylamino)-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate | C46H75NO17 | 详情 | 详情 | |
| (III) | 62003 | (2S,3S,4R,6R)-6-{[(2R,3S,4S,5R,6R)-5-(acetyloxy)-6-{[(4R,5R,6S,8R,9R,10R,14R)-4-(acetyloxy)-8-(2,2-dimethoxyethyl)-10-hydroxy-5-methoxy-9,14-dimethyl-2-oxooxa-11-cyclotetradecen-6-yl]oxy}-4-(dimethylamino)-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate | C44H75NO17 | 详情 | 详情 | |
| (IV) | 62007 | (2S,3S,4R,6R)-6-{[(2R,3S,4S,5R,6R)-5-(acetyloxy)-6-{[(4R,5R,6S,8R,9R,10S,14R)-4-(acetyloxy)-10-azido-8-(2,2-dimethoxyethyl)-5-methoxy-9,14-dimethyl-2-oxooxa-11-cyclotetradecen-6-yl]oxy}-4-(dimethylamino)-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate | C44H74N4O16 | 详情 | 详情 | |
| (V) | 62008 | (2S,3S,4R,6R)-6-{[(2R,3S,4S,5R,6R)-5-(acetyloxy)-6-{[(4R,5R,6S,8R,9R,10S,14R)-4-(acetyloxy)-10-amino-8-(2,2-dimethoxyethyl)-5-methoxy-9,14-dimethyl-2-oxooxa-11-cyclotetradecen-6-yl]oxy}-4-(dimethylamino)-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate | C44H76N2O16 | 详情 | 详情 | |
| (VI) | 62009 | (2S,3S,4R,6R)-6-{[(2R,3S,4S,5R,6R)-5-(acetyloxy)-6-{[(4R,5R,6S,8R,9R,10S,14R)-4-(acetyloxy)-8-(2,2-dimethoxyethyl)-10-(dimethylamino)-5-methoxy-9,14-dimethyl-2-oxooxa-11-cyclotetradecen-6-yl]oxy}-4-(dimethylamino)-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate | C46H80N2O16 | 详情 | 详情 |