【结 构 式】 |
【药物名称】 【化学名称】2-(Acetoxymethyl)-4(S)-[2-[5-(benzyloxycarbonylamino)-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-yl]acetamido]-2-pentenoic acid methyl ester 【CA登记号】 【 分 子 式 】C29H30N4O8 【 分 子 量 】562.58445 |
【开发单位】Walter Reed Army Institute (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antimalarials, Treatment of Protozoal Diseases |
合成路线1
The Baylis-Hillman reaction between N-Boc-alaninal (I) and methyl acrylate (II) in the presence of DABCO yields the allylic alcohol adduct (III). Subsequent Mitsunobu coupling with acetic acid leads to the rearranged allylic acetate (IV). Acidic Boc group cleavage in (IV) then gives the amino ester intermediate (V).
【1】 Zhu, S.; et al.; Synthesis and in vitro studies of novel pyrimidinyl peptidomimetics as potential antimalarial therapeutic agents. J Med Chem 2002, 45, 16, 3491. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 59029 | tert-butyl (1S)-1-methyl-2-oxoethylcarbamate | C8H15NO3 | 详情 | 详情 | |
(II) | 14156 | methyl acrylate | 96-33-3 | C4H6O2 | 详情 | 详情 |
(III) | 59026 | methyl 2-{(2S)-2-[(tert-butoxycarbonyl)amino]-1-hydroxypropyl}acrylate | C12H21NO5 | 详情 | 详情 | |
(IV) | 59027 | methyl (E,4S)-2-[(acetyloxy)methyl]-4-[(tert-butoxycarbonyl)amino]-2-pentenoate | C14H23NO6 | 详情 | 详情 | |
(V) | 59028 | methyl (E,4S)-2-[(acetyloxy)methyl]-4-amino-2-pentenoate | C9H15NO4 | 详情 | 详情 |
合成路线2
The pyrimidinone acetaldehyde (VI) is oxidized to the corresponding acid (VII) by means of sodium chlorite. Then, coupling of acid (VII) with amino ester (V) using DCC and HOBt provides the target amide.
【1】 Zhu, S.; et al.; Synthesis and in vitro studies of novel pyrimidinyl peptidomimetics as potential antimalarial therapeutic agents. J Med Chem 2002, 45, 16, 3491. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(V) | 59028 | methyl (E,4S)-2-[(acetyloxy)methyl]-4-amino-2-pentenoate | C9H15NO4 | 详情 | 详情 | |
(VI) | 51965 | benzyl 6-oxo-1-(2-oxoethyl)-2-phenyl-1,6-dihydro-5-pyrimidinylcarbamate | C20H17N3O4 | 详情 | 详情 | |
(VII) | 47808 | 2-[5-[[(benzyloxy)carbonyl]amino]-6-oxo-2-phenyl-1(6H)-pyrimidinyl]acetic acid | C20H17N3O5 | 详情 | 详情 |