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【结 构 式】

【药物名称】

【化学名称】2-(Acetoxymethyl)-4(S)-[2-[5-(benzyloxycarbonylamino)-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-yl]acetamido]-2-pentenoic acid methyl ester
      N-[1-[N-[3-(Acetoxymethyl)-4-methoxy-1(S)-methyl-4-oxo-2-butenyl]carbamoylmethyl]-6-oxo-2-phenyl-1,6-dihydropyrimidin-5-yl]carbamic acid benzyl ester

【CA登记号】

【 分 子 式 】C29H30N4O8

【 分 子 量 】562.58445

【开发单位】Walter Reed Army Institute (Originator)

【药理作用】ANTIINFECTIVE THERAPY, Antimalarials, Treatment of Protozoal Diseases

合成路线1

The Baylis-Hillman reaction between N-Boc-alaninal (I) and methyl acrylate (II) in the presence of DABCO yields the allylic alcohol adduct (III). Subsequent Mitsunobu coupling with acetic acid leads to the rearranged allylic acetate (IV). Acidic Boc group cleavage in (IV) then gives the amino ester intermediate (V).

1 Zhu, S.; et al.; Synthesis and in vitro studies of novel pyrimidinyl peptidomimetics as potential antimalarial therapeutic agents. J Med Chem 2002, 45, 16, 3491.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 59029 tert-butyl (1S)-1-methyl-2-oxoethylcarbamate C8H15NO3 详情 详情
(II) 14156 methyl acrylate 96-33-3 C4H6O2 详情 详情
(III) 59026 methyl 2-{(2S)-2-[(tert-butoxycarbonyl)amino]-1-hydroxypropyl}acrylate C12H21NO5 详情 详情
(IV) 59027 methyl (E,4S)-2-[(acetyloxy)methyl]-4-[(tert-butoxycarbonyl)amino]-2-pentenoate C14H23NO6 详情 详情
(V) 59028 methyl (E,4S)-2-[(acetyloxy)methyl]-4-amino-2-pentenoate C9H15NO4 详情 详情

合成路线2

The pyrimidinone acetaldehyde (VI) is oxidized to the corresponding acid (VII) by means of sodium chlorite. Then, coupling of acid (VII) with amino ester (V) using DCC and HOBt provides the target amide.

1 Zhu, S.; et al.; Synthesis and in vitro studies of novel pyrimidinyl peptidomimetics as potential antimalarial therapeutic agents. J Med Chem 2002, 45, 16, 3491.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(V) 59028 methyl (E,4S)-2-[(acetyloxy)methyl]-4-amino-2-pentenoate C9H15NO4 详情 详情
(VI) 51965 benzyl 6-oxo-1-(2-oxoethyl)-2-phenyl-1,6-dihydro-5-pyrimidinylcarbamate C20H17N3O4 详情 详情
(VII) 47808 2-[5-[[(benzyloxy)carbonyl]amino]-6-oxo-2-phenyl-1(6H)-pyrimidinyl]acetic acid C20H17N3O5 详情 详情
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