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【结 构 式】 
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【药物名称】INS-48848 【化学名称】N-(1-Oxo-2,3,4,9-tetrahydro-1H-beta-carbolin-6-yl)carbamic acid methyl ester 【CA登记号】393835-84-2 【 分 子 式 】C13H13N3O3 【 分 子 量 】259.26686 |
【开发单位】Inspire Pharmaceuticals (Originator) 【药理作用】Antiglaucoma Agents, OCULAR MEDICATIONS, Ophthalmic Drugs, Melatonin Analogs |
合成路线1
The reduction of 6-nitro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one (I) with H2 over Pd/C in ethanol gives the corresponding 6-amino derivative (II), which is condensed with methyl chloroformate (III) and pyridine to afford the target carbamate.
| 【1】 Yerxa, B.R.; Peterson, W.M.; Pintor, J.J.; Peral, M.A.; Plourde, R. Jr.; Brown, E.G. (Inspire Pharmaceuticals, Inc.; Universidad Complutense de Madrid); Method for reducing intraocular pressure using indole derivs.. WO 0209702 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 57858 | 6-Nitro-2,3,4,9-tetrahydro-beta-carbolin-1-one | C11H9N3O3 | 详情 | 详情 | |
| (II) | 57859 | 6-amino-2,3,4,9-tetrahydro-1H-beta-carbolin-1-one | C11H11N3O | 详情 | 详情 | |
| (III) | 16993 | methyl chlorocarbonate;Carbonochloridic acid methyl ester；[(chlorocarbonyl)oxy]methane；methyl chloroformate | 79-22-1 | C2H3ClO2 | 详情 | 详情 |
Extended Information