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【结 构 式】

【药物名称】IND-12

【化学名称】2-[(Z)-5-Fluoro-1-(furan-3-ylmethylidene)-2-methyl-1H-inden-3-yl]acetic acid

【CA登记号】

【 分 子 式 】C17H13FO3

【 分 子 量 】284.28976

【开发单位】Max-Planck-Gesellschaft (Originator), Squarix (Originator), Universität Konstanz (Originator), Universitätsklin., Essen (Originator), Westfälische Wilhelms-Univ. Münster (Originator)

【药理作用】Oncolytic Drugs, Cyclooxygenase Inhibitors

合成路线1

The title compound is prepared by condensation between 5-fluoro-2-methylindene-3-acetic acid (I) and 3-furaldehyde (II) in the presence of NaOMe.

1 Karaguni, I.-M.; et al.; New indene-derivatives with anti-proliferative properties. Bioorg Med Chem Lett 2002, 12, 4, 709.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 48874 2-(5-fluoro-2-methyl-1H-inden-3-yl)acetic acid C12H11FO2 详情 详情
(II) 47247 3-Furaldehyde 498-60-2 C5H4O2 详情 详情
Extended Information