-Drug Synthesis Database

【结构式】

【药物名称】

【化学名称】3,5-Dibenzoyl-4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine
　　　　　　[4-(3-Chlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinediyl]bis(phenylmethanone)

【CA登记号】359764-00-4

【分子式】C₂₇H₂₂ClNO₂

【分子量】427.93489

【开发单位】Albert Szent-Györgyi Medical Univ. (Originator), Humboldt-Universität zu Berlin (Originator), Josai University (Originator), Meiji Pharmaceutical University (Originator), Saurashtra University (Originator)

【药理作用】Antibacterial Activity Enhancers, Antibacterial Drugs, ANTIINFECTIVE THERAPY, Modulators of the Therapeutic Activity of Antineoplastic Agents, Multidrug Resistance Modulators, ONCOLYTIC DRUGS, P-Glycoprotein (MDR-1) Inhibitors

合成路线1

The title dihydropyridine is prepared by condensation of benzoylacetone (I) with 3-chlorobenzaldehyde (II) in the presence of aqueous ammonia, following a variation of the Hantzsch reaction.

参考文献中间体

【1】 Kawase, M.; et al.; 3,5-Dibenzoyl-1,4-dihydropyridines: Synthesis and MDR reversal in tumor cells. Bioorg Med Chem 2002, 10, 4, 1051.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23829	1-phenyl-1,3-butanedione	93-91-4	C₁₀H₁₀O₂	详情	详情
(II)	13660	3-Chlorobenzaldehyde	587-04-2	C₇H₅ClO	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)