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【结 构 式】 
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【药物名称】D-82318 【化学名称】1-(9-Acridinyl)-1-[4-(3-methoxyphenyl)piperazin-1-yl]methanone 【CA登记号】 【 分 子 式 】C25H23N3O2 【 分 子 量 】397.48096 |
【开发单位】Zentaris (Originator) 【药理作用】Oncolytic Drugs, Solid Tumors Therapy, Antimitotic Drugs, Microtubule-Stabilizing Agents |
合成路线1
The title amide is prepared by coupling between 9-acridinecarboxylic acid (I) and N-(3-methoxyphenyl)piperazine (II) in the presence of PyBOP and NMM
| 【1】 Emig, P.; Gunther, E.; Beckers, T.; Baasner, S.; Bcher, G.; Aue, B. (Zentaris AG); Novel heteroaryl derivs. and the use thereof as pharmaceuticals. EP 1301485; WO 0208194 . |
Extended Information