MX-76629, -Drug Synthesis Database

【结构式】

【药物名称】MX-76629

【化学名称】N-(4-Ethoxy-2-nitrophenyl)-6-methylpyridine-3-carboxamide

【CA登记号】352228-58-1

【分子式】C₁₅H₁₅N₃O₄

【分子量】301.3045

【开发单位】Maxim (Originator)

【药理作用】ONCOLYTIC DRUGS, Apoptosis Inducers

合成路线1

The title amide is obtained by condensation of 6-methylpyridine-3-carboxylic acid (I) with 4-ethoxy-2-nitroaniline by means of cyanuric chloride and TEA in dichloromethane.

参考文献中间体

【1】 Cai, S.X.; Drewe, J.A. (Cytovia, Inc.); Substd. nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof. WO 0155115 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	42889	4-toluic acid; 4-methylbenzoic acid	99-94-5	C₈H₈O₂	详情	详情
(II)	53589	2-Nitro-p-phenetidine; 4-Amino-3-nitrophenetole; 4-Ethoxy-2-nitroaniline; 4-Ethoxy-2-nitrobenzeneamine	616-86-4	C₈H₁₀N₂O₃	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)