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【结 构 式】

【药物名称】Methypranolol, Metipranolol, VUFB-6453, VUAB-6453, BMOI-004, Turoptin, Betanol, Minims metipranolol, Optipranolol

【化学名称】Acetic acid 4-[2-hydroxy-3-(isopropylamino)propoxy]-2,3,6-trimethylphenyl ester

【CA登记号】22664-55-7

【 分 子 式 】C17H27NO4

【 分 子 量 】309.40904

【开发单位】Bausch & Lomb (Originator), Chauvin (Originator), Novartis Ophthalmics (Not Determined)

【药理作用】Antiglaucoma Agents, OCULAR MEDICATIONS, Ophthalmic Drugs

合成路线1

The condensation of the epoxide (I) with isopropylamine (II) gives the target isopropanol derivative.

1 Zolss, G.; Pfarrhofer, G. (Aventis Pharma AG); Novel crystalline salts of aryloxy-propanolamines, a process for their preparation and their use. DE 3544172; EP 0229947; US 4767784 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 62420 2,3,6-trimethyl-4-(2-oxiranylmethoxy)phenyl acetate C14H18O4 详情 详情
(II) 23933 2-Propanamine; Isopropylamine 75-31-0 C3H9N 详情 详情
Extended Information