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【结 构 式】 
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【药物名称】C-6458 【化学名称】4-Amino-5-(1H-indol-1-ylmethyl)-3,4-dihydro-2H-1,2,4-triazole-3-thione 【CA登记号】 【 分 子 式 】C11H11N5S 【 分 子 量 】245.30782 |
【开发单位】Aristotle University of Thessaloniki (Originator), Onassis Cardiac Surgery Center (Originator), University of Athens (Originator) 【药理作用】Acute Myocardial Infarction, Treatment of, CARDIOVASCULAR DRUGS, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Antioxidants, Free Radical Scavengers, Lipid Peroxidation Inhibitors |
合成路线1
Condensation of indolyl acetohydrazide (I) with carbon disulfide in the presence of KOH afforded the potassium dithiocarbazate (II), which was further cyclized to the target aminotriazole thione upon refluxing with aqueous hydrazine.
| 【1】 Andreadou, I.; et al.; Antioxidant activity of novel indole derivatives and protection of the myocardial damage in rabbits. Chem Pharm Bull 2002, 50, 2, 165. |
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