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【结 构 式】 
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【药物名称】ZYC-3 【化学名称】2-(1-Adamantyl)-3-hydroxyestra-1,3,5(10)-trien-17-one 【CA登记号】21003-01-0 【 分 子 式 】C28H36O2 【 分 子 量 】404.59792 |
【开发单位】Univ. North Texas Health Science Center (Originator), University of Florida (Originator), Washington University (Originator) 【药理作用】Cerebrovascular Diseases, Treatment of, Ischemic Stroke, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of |
合成路线1
The title compound is obtained by Friedel-Crafts alkylation of estrone (I) with 1 adamantanol (II) in the presence of boron trifluoride etherate.
| 【1】 Covey, D.F. (Washington University); Modified, hydroxy-substd. aromatic structures having cytoprotective activity. WO 0236605 . |
Extended Information