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【结 构 式】 
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【药物名称】 【化学名称】5-Ethyl-2-(methylsulfanylmethylsulfanyl)-6-(1-naphthylmethyl)pyrimidin-4(3H)-one 【CA登记号】 【 分 子 式 】C19H20N2OS2 【 分 子 量 】356.51205 |
【开发单位】 【药理作用】 |
合成路线1
The condensation of 2-(1-naphthyl)acetonitrile (I) with 2-bromobutyric acid ethyl ester (II) by means of K2CO3 gives 2-ethyl-4-(!-naphthyl)-3-oxobutyric acid ethyl ester (III), which is cyclized with thiourea (IV) by means of NaOMe yielding 5-ethyl-6-(1-naphthylmethyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-one (V). Finally this compound is condensed with methylsulfanylmethyl iodide (VI) to afford the title pyrimidinone derivative.
| 【1】 Artico, M.; Selected non-nucleoside reverse transcriptase inhibitors (NNRTIs): the DABOs family. Drugs Fut 2002, 27, 2, 159. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18587 | 2-(1-naphthyl)acetonitrile | 132-75-2 | C12H9N | 详情 | 详情 |
| (II) | 36668 | ethyl 2-bromobutanoate | 533-68-6 | C6H11BrO2 | 详情 | 详情 |
| (III) | 51802 | ethyl 2-ethyl-4-(1-naphthyl)-3-oxobutanoate | C18H20O3 | 详情 | 详情 | |
| (IV) | 10180 | Thiourea | 62-56-6 | CH4N2S | 详情 | 详情 |
| (V) | 51803 | 5-ethyl-6-(1-naphthylmethyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone | C17H16N2OS | 详情 | 详情 | |
| (VI) | 51805 | iodomethyl methyl sulfide; iodo(methylsulfanyl)methane | C2H5IS | 详情 | 详情 |
Extended Information