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【结 构 式】 
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【药物名称】 【化学名称】6-Benzyl-5-methyl-2-(1-methylpropylsulfanyl)pyrimidin-4(3H)-one 【CA登记号】 【 分 子 式 】C16H20N2OS 【 分 子 量 】288.4146 |
【开发单位】 【药理作用】 |
合成路线1
When 2-methyl-4-phenyl-3-oxobutanoic acid methyl ester (I) were reacted with thiourea (II), in the presence of sodium methoxide, condensation occurred with formation of 5-methyl-3,4-dihydro-6-benzyl-4-oxo-2-thioxopyrimidine (III). Reaction of compound (III) with sec-butyl chloride (IV) in alkaline medium afforded the required 2-(sec-butylthio)-5-methyl-6-benzyl-3,4-dihydro-4-oxopyrimidine
| 【1】 Artico, M.; Selected non-nucleoside reverse transcriptase inhibitors (NNRTIs): the DABOs family. Drugs Fut 2002, 27, 2, 159. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 51789 | methyl (Z)-3-hydroxy-2-methyl-4-phenyl-2-butenoate | C12H14O3 | 详情 | 详情 | |
| (II) | 10180 | Thiourea | 62-56-6 | CH4N2S | 详情 | 详情 |
| (III) | 51800 | 6-benzyl-5-methyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone | C12H12N2OS | 详情 | 详情 | |
| (IV) | 51797 | 1-methylpropyl chloride; 2-Chlorobutane; 1-Chloro-1-methylpropane; Sec-Butyl Chloride | 78-86-4 | C4H9Cl | 详情 | 详情 |
Extended Information