|
【结 构 式】 
|
【药物名称】 【化学名称】6-Benzyl-2-(isopropylsulfanyl)pyrimidin-4(3H)-one 【CA登记号】 【 分 子 式 】C14H16N2OS 【 分 子 量 】260.36042 |
【开发单位】 【药理作用】 |
合成路线1
When 4-phenyl-3-oxobutanoic acid methyl ester (I) were reacted with thiourea (II), in the presence of sodium methoxide, condensation occurred with formation of 3,4-dihydro-6-benzyl-4-oxo-2-thioxopyrimidine (III). Reaction of the compound (III) with isopropyl chloride (IV) in alkaline medium afforded the required 2-(isopropylthio)-6-benzyl-3,4-dihydro-4-oxopyrimidine
| 【1】 Artico, M.; Selected non-nucleoside reverse transcriptase inhibitors (NNRTIs): the DABOs family. Drugs Fut 2002, 27, 2, 159. |
Extended Information