• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【药物名称】

【化学名称】2-(Cyclohexyloxy)-6-(3,5-dimethylbenzyl)-5-methylpyrimidin-4(3H)-one

【CA登记号】

【 分 子 式 】C20H26N2O2

【 分 子 量 】326.44242

【开发单位】

【药理作用】 

合成路线1

Condensation of 2-methyl-4-(3,5-dimethylphenyl)-3-oxobutanoic acid methyl ester (I) with O-methyl isourea (II) led to the formation of 5-methyl-6-(3,5-dimethylbenzyl)-3,4-dihydro-2-methoxy-4-oxopyrimidine (III). Subsequent displacement of the methoxy group linked at C-2 of the pyrimidine ring by treatment with cyclohexoxy potassium salt furnished 2-cyclohexoxy-5-methyl-6-(3,5-dimethylphenyl)-3,4-dihydro-4-oxopyrimidine

1 Artico, M.; Selected non-nucleoside reverse transcriptase inhibitors (NNRTIs): the DABOs family. Drugs Fut 2002, 27, 2, 159.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 51781 methyl (Z)-4-(3,5-dimethylphenyl)-3-hydroxy-2-methyl-2-butenoate C14H18O3 详情 详情
(II) 26657 O-methyl isourea; [Amino(imino)methoxy]methane 52328-05-9 C2H6N2O 详情 详情
(III) 51782 6-(3,5-dimethylbenzyl)-2-methoxy-5-methyl-4(3H)-pyrimidinone C15H18N2O2 详情 详情
(IV) 51780 sodium cyclohexanolate C6H11NaO 详情 详情
Extended Information