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【结 构 式】 
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【药物名称】 【化学名称】6-Benzyl-2-(1-methylpropoxy)pyrimidin-4(3H)-one 【CA登记号】 【 分 子 式 】C15H18N2O2 【 分 子 量 】258.32291 |
【开发单位】 【药理作用】 |
合成路线1
Condensation of 4-phenyl-3-oxobutanoic acid methyl ester (I) with O-methyl isourea (II) led to the formation of 6-benzyl-3,4-dihydro-2-methoxy-4-oxopyrimidine (III). Subsequent displacement of the methoxy group linked at C-2 of the pyrimidine ring by treatment with isobutoxy sodium salt (IV) furnished 2-isobutoxy-6-benzyl-3,4-dihydro-4-oxopyrimidine
| 【1】 Artico, M.; Selected non-nucleoside reverse transcriptase inhibitors (NNRTIs): the DABOs family. Drugs Fut 2002, 27, 2, 159. |
Extended Information