|
【结 构 式】 
|
【药物名称】 【化学名称】6-Benzyl-2-(cyclopentylsulfanyl)pyrimidin-4(3H)-one 【CA登记号】 【 分 子 式 】C16H18N2OS 【 分 子 量 】286.39866 |
【开发单位】 【药理作用】 |
合成路线1
When 4-phenyl-3-oxobutanoic acid methyl ester (I) were reacted with thiourea (II), in the presence of sodium methoxide, condensation occurred with formation of 3,4-dihydro-6-benzyl-4-oxo-2-thioxopyrimidine (III). Reaction of compound (III) with cyclopentyl chloride (IV) in alkaline medium afforded the required 2-(cyclopentylthio)-6-benzyl-3,4-dihydro-4-oxopyrimidine.
| 【1】 Artico, M.; Selected non-nucleoside reverse transcriptase inhibitors (NNRTIs): the DABOs family. Drugs Fut 2002, 27, 2, 159. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 51791 | methyl (Z)-3-hydroxy-4-phenyl-2-butenoate | C11H12O3 | 详情 | 详情 | |
| (II) | 10180 | Thiourea | 62-56-6 | CH4N2S | 详情 | 详情 |
| (III) | 51793 | 6-benzyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone | C11H10N2OS | 详情 | 详情 | |
| (IV) | 51794 | 1-Chlorocyclopentane; Chlorocyclopentane; cyclopentyl chloride | 930-28-9 | C5H9Cl | 详情 | 详情 |
Extended Information