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【结 构 式】 
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【药物名称】SU-5614 【化学名称】(Z)-5-Chloro-3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-2-one 【CA登记号】186611-56-3 【 分 子 式 】C15H13ClN2O 【 分 子 量 】272.73666 |
【开发单位】Sugen (Originator) 【药理作用】Leukemia Therapy, Oncolytic Drugs, Angiogenesis Inhibitors, Flt3 (FLK2/STK1) Inhibitors, PDGFR Inhibitors, VEGFR-2 (FLK-1/KDR) Inhibitors |
合成路线1
Aldehyde (II) was prepared by Vilsmeier-Haack formylation of 2,4-dimethylpyrrole (I). Subsequent condensation of the pyrrole aldehyde (II) with 5-chlorooxindole (III) in the presence of piperidine furnished the title compound.
| 【1】 Tang, P.C.; Sun, L.; McMahon, G. (Sugen, Inc.); Indolinone cpds. for the treatment of disease. EP 0769947; JP 2000026412; US 5780496; US 5792783; US 5880141; US 5883113; US 5883116; WO 9640116 . |
Extended Information