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【结 构 式】 
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【药物名称】SLV-319 【化学名称】4-Chloro-N-[1-[3-(4-chlorophenyl)-4(S)-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-1-(methylamino)methylidene]benzenesulfonamide 【CA登记号】362519-49-1 (racemate) 【 分 子 式 】C23H20Cl2N4O2S 【 分 子 量 】487.41145 |
【开发单位】Solvay (Originator) 【药理作用】Antiobesity Drugs, Antipsychotic Drugs, METABOLIC DRUGS, PSYCHOPHARMACOLOGIC DRUGS, Treatment of Nutritional Disorders, Cannabinoid CB1 Antagonists |
合成路线1
Condensation of dihydropyrazole (I) with the sulfonyl carbamate (II) in the presence of pyridine gives rise to the 1-acyl dihydropyrazole (III). Subsequent chlorination of (III) using PCl5 in refluxing chlorobenzene affords the imidoyl chloride (IV). This is finally condensed with methylamine in CH2Cl2 to furnish the title compound.
| 【1】 Kruse, C.G.; Tulp, M.T.M.; Lange, J.H.M.; Tipker, J.; Van Vliet, B.J. (Solvay Pharmaceuticals BV); 4,5-Dihydro-1H-pyrazole derivs. having CB 1-antagonistic activity. EP 1268435; US 2001053788; US 6476060; WO 0170700 . |
| 【2】 Kruse, C.G.; Lange, J.H.M.; Tipker, J.; Hoogendoorn, J. (Solvay Pharmaceuticals BV); 4,5-Dihydro-1H-pyrazole derivs. having CB1-antagonistic activity. WO 0276949 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 58393 | 3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazole | C15H13ClN2 | 详情 | 详情 | |
| (II) | 15813 | methyl N-[(4-chlorophenyl)sulfonyl]carbamate | C8H8ClNO4S | 详情 | 详情 | |
| (III) | 58394 | 4-chloro-N-{[3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl]carbonyl}benzenesulfonamide | C22H17Cl2N3O3S | 详情 | 详情 | |
| (IV) | 58395 | 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidoyl chloride | C22H16Cl3N3O2S | 详情 | 详情 |