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【结 构 式】 
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【药物名称】 【化学名称】6-(3-Methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)hexanoic acid 3-(7-chloroquinolin-4-ylamino)-5-[2-(1-piperidinyl)acetamido]benzyl ester 【CA登记号】 【 分 子 式 】C40H41ClN4O5 【 分 子 量 】693.24957 |
【开发单位】CNRS (Originator), Tibotec-Virco (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antimalarials, Chemical Delivery Systems, DRUG DELIVERY, Drug Delivery Systems, Treatment of Protozoal Diseases, Glutathione Reductase (NADPH) Inhibitors |
合成路线1
The title ester is obtained by condensation of benzyl alcohol (I) with the hexanoic acid (II) by means of DCC and DMAP in dichloromethane.
| 【1】 Biot, C.; Delarue, S.; Davioud-Chervet, E.; et al.; A prodrug from of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline. J Med Chem 2001, 44, 24, 4268. |
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