SM-18163, -Drug Synthesis Database

【结构式】

【药物名称】SM-18163

【化学名称】4-[1-(1,3-Benzodioxol-5-ylcarbonyl)piperidin-4-yl]-6-(4-methoxybenzyl)pyrimidin-2-amine
　　　　　　1-[4-[2-Amino-6-(4-methoxybenzyl)pyrimidin-4-yl]piperidin-1-yl]-1-(1,3-benzodioxol-5-yl)methanone

【CA登记号】198553-25-2

【分子式】C₂₅H₂₆N₄O₄

【分子量】446.51037

【开发单位】Sumitomo Pharmaceuticals (Originator)

【药理作用】Antiarthritic Drugs, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, TNF-alpha Production Inhibitors

合成路线1

N-Benzoylisonipecotic acid (I) was chlorinated with SOCl2 to produce the corresponding acid chloride (II). Acylation of the lithium enolate of (4-methoxyphenyl)acetone (III) with acid chloride (II) provided a mixture of diketone regioisomers (IV) and (V); these were separated by column chromatography. The desired diketone (IV) was then cyclized with guanidine (VI) in hot pyridine to afford the pyrimidine (VII). Basic hydrolysis of the benzamide function of (VII) gave the piperidine derivative (VIII). The target amide was finally prepared by acylation of (VIII) with 3,4-methylenedioxybenzoic acid (IX) in the presence of EDC.

参考文献中间体

【1】 Kawakami, H.; Kurimoto, A.; Murata, S.; Fujita, H.; Iwai, K.; Fujiwara, N.; Synthesis and bioactivities of novel piperidylpyrimidine derivatives: Inhibitors of tumor necrosis factor-alpha production. Bioorg Med Chem Lett 2000, 10, 12, 1317.
【2】 Fujiwara, N.; Ueda, Y.; Murata, S.; Hirota, F.; Kawakami, H.; Fujita, H. (Sumitomo Pharmaceuticals Co., Ltd.); Piperidinylpyramidine derivs.. EP 0892795; JP 2001511764; US 5948786; WO 9738992 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	52892	1-benzoyl-4-piperidinecarboxylic acid		C₁₃H₁₅NO₃	详情	详情
(II)	52893	1-benzoyl-4-piperidinecarbonyl chloride		C₁₃H₁₄ClNO₂	详情	详情
(III)	10038	4-Methoxyphenylacetone; 1-(4-Methoxyphenyl)acetone	122-84-9	C₁₀H₁₂O₂	详情	详情
(IV)	52894	1-(1-benzoyl-4-piperidinyl)-4-(4-methoxyphenyl)-1,3-butanedione		C₂₃H₂₅NO₄	详情	详情
(V)	52895	1-(1-benzoyl-4-piperidinyl)-2-(4-methoxyphenyl)-1,3-butanedione		C₂₃H₂₅NO₄	详情	详情
(VI)	14790	Guanidine	113-00-8	CH₅N₃	详情	详情
(VII)	52896	{4-[2-amino-6-(4-methoxybenzyl)-4-pyrimidinyl]-1-piperidinyl}(phenyl)methanone		C₂₄H₂₆N₄O₂	详情	详情
(VIII)	52897	4-(4-methoxybenzyl)-6-(4-piperidinyl)-2-pyrimidinamine; 4-(4-methoxybenzyl)-6-(4-piperidinyl)-2-pyrimidinylamine		C₁₇H₂₂N₄O	详情	详情
(IX)	10125	1,3-Benzodioxole-5-carboxylic acid	94-53-1	C₈H₆O₄	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)