-Drug Synthesis Database

【结构式】

【药物名称】

【化学名称】9-[2-[[2(Z)-(3,4-Dimethoxy-5-oxo-2,5-dihydrofuran-2-ylidene)ethoxy](hydroxy)phosphorylmethoxy]ethyl]adenine
　　　　　　[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid 2(Z)-(3,4-dimethoxy-5-oxo-2,5-dihydrofuran-2-ylidene)ethyl ester

【CA登记号】

【分子式】C₁₆H₂₀N₅O₈P

【分子量】441.3403

【开发单位】Academia Sinica (Originator), China Medical College (Originator), Purdue University (Originator), Shiraz University (Originator), University of Tehran (Originator)

【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Antiviral Drugs, Chemical Delivery Systems, DRUG DELIVERY, Drug Delivery Systems

合成路线1

The condensation of 9-[2-(phosphonomethoxy)ethyl]adenine (I) with butenolide (II) by means of NaHCO3 in hot DMF gives the target phosphonate monoester.

参考文献中间体

【1】 Hakimelahi, G.H.; et al.; Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses. J Med Chem 2001, 44, 22, 3710.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	16165	[2-(6-amino-9H-purin-9-yl)ethoxy]methylphosphonic acid		C₈H₁₂N₅O₄P	详情	详情
(II)	52430	5-(2-chloroethylidene)-3,4-bis(methyloxy)-2(5H)-furanone		C₈H₉ClO₄	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)