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【结 构 式】 
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【药物名称】LY-508869 【化学名称】2,2,2-Trifluoro-N-[3-(2-methoxyphenoxy)phenyl]-N-(pyridin-3-ylmethyl)ethanesulfonamide 【CA登记号】353229-45-5, 353235-52-6 (hydrochloride) 【 分 子 式 】C21H19F3N2O4S 【 分 子 量 】452.45578 |
【开发单位】Lilly (Originator) 【药理作用】Anxiolytics, PSYCHOPHARMACOLOGIC DRUGS, mglu2 Agonists |
合成路线1
Coupling of 2-methoxyphenol (I) with 3-fluoronitrobenzene (II) produced the diaryl ether (III). The nitro group of (III) was then reduced by catalytic hydrogenation over Raney-Ni, yielding aniline (IV). Reductive alkylation of (IV) with pyridine-3-carboxaldehyde (V) using NaBH4 furnished the secondary amine (VI). This was finally acylated with 2,2,2-trifluoroethylsulfonyl chloride to produce the title sufonamide.
| 【1】 Monn, J.A.; Hornback, W.J.; Schoepp, D.D.; Dressman, B.A.; Britton, T.C.; Tizzano, J.P.; Johnson, K.W.; Henry, S.S.; Coleman, D.S.; Jagdmann, G.E.J.; Johnson, M.P.; Large, T.H.; Barda, D.A.; Fichtner, M.W. (Eli Lilly and Company); Potentiators of glutamate receptors. WO 0156990 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13182 | Guaiacol; 2-Methoxyphenol | 90-05-1 | C7H8O2 | 详情 | 详情 |
| (II) | 55157 | 1-Fluoro-3-nitrobenzene; 3-Fluoro-1-nitrobenzene; 3-Fluoronitrobenzene; 3-Nitrofluorobenzene; m-Fluoronitrobenzene | 402-67-5 | C6H4FNO2 | 详情 | 详情 |
| (III) | 55158 | 2-methoxyphenyl 3-nitrophenyl ether; 1-methoxy-2-(3-nitrophenoxy)benzene | C13H11NO4 | 详情 | 详情 | |
| (IV) | 55159 | 3-(2-methoxyphenoxy)phenylamine; 3-(2-methoxyphenoxy)aniline | C13H13NO2 | 详情 | 详情 | |
| (V) | 12849 | Nicotinaldehyde; 3-Pyridinecarboxaldehyde | 500-22-1 | C6H5NO | 详情 | 详情 |
| (VI) | 55160 | 3-(2-methoxyphenoxy)-N-(3-pyridinylmethyl)aniline; N-[3-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)amine | C19H18N2O2 | 详情 | 详情 |
Extended Information