-Drug Synthesis Database

【结构式】

【药物名称】

【化学名称】2-(2,6-Dichlorophenyl)-3-(6-methylpyridin-2-yl)thiazolidin-4-one

【CA登记号】

【分子式】C₁₅H₁₂Cl₂N₂OS

【分子量】339.24569

【开发单位】Rega Institute for Medical Research (Originator), Università degli Studi di Catanzaro (Originator), Università degli Studi di Messina (Originator)

【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Reverse Transcriptase Inhibitors

合成路线1

The title diaryl thiazolidinone was synthesized by condensation between 2,6-dichlorobenzaldehyde (I), 2-amino-6-methylpyridine (II) and mercaptoacetic acid (III) in refluxing toluene.

参考文献中间体

【1】 Barreca, M.L.; et al.; Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents. Bioorg Med Chem Lett 2001, 11, 13, 1793.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	27507	2,6-dichlorobenzaldehyde	83-38-5	C₇H₄Cl₂O	详情	详情
(II)	19678	6-methyl-2-pyridinamine; 6-methyl-2-pyridinylamine; 6-amino-2-picoline; 2-Amino-6-methylpyridine	1824-81-3	C₆H₈N₂	详情	详情
(III)	18524	2-sulfanylacetic acid	68-11-1	C₂H₄O₂S	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)